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Dream neuronal calcium sensor-modulating compounds, and therapeutic uses thereof

Authors: Gutiérrez-Rodríguez, Marta; Cercós, Pilar; Martín-Martínez, Mercedes; Herranz, Rosario; García-López, M. Teresa; Valenzuela, Carmen; Naranjo, José Ramón; +3 Authors

Dream neuronal calcium sensor-modulating compounds, and therapeutic uses thereof

Abstract

[ES] Compuestos moduladores del sensor neuronal de calcio dream y sus usos terapéuticos. La presente invención se refiere a un grupo de compuestos con un núcleo estructural derivado de fenilacetamida con la siguiente fórmula (I): que presentan capacidad de modulación del sensor neuronal de calncio DREAM, por lo que la presente invención también se refiere al uso de estos compuestos para el tratamiento o prevención de trastornos o enfermedades donde los niveles de DREAM están por encima o por debajo de los niveles considerados fisiológicamente normales.

[EN] The invention relates to a group of compounds with a structural nucleus derived from phenylacetamide, having formula (I), which compounds can modulate the DREAM neuronal calcium sensor. Consequently, the invention also relates to the use of these compounds for the treatment or prevention of disorders or diseases in which DREAM levels are above or below physiologically normal levels.

Consejo Superior de Investigaciones Científicas (España), Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) y Universidad Autónoma de Madrid

A1 Solicitud de patente con informe sobre el estado de la técnica

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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