Getting CAD in Shape: The Atomic Structure of Human Dihydroorotase Domain

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2014 English Publisher:Elsevier BVJournal:Structure, volume 22, pages 179-181 (issn: 0969-2126,

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Authors: Hermoso, Juan A.;

doi: 10.1016/j.str.2014.01.005

pmid: 24507779

handle: 10261/167734

Getting CAD in Shape: The Atomic Structure of Human Dihydroorotase Domain

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Abstract

CAD is a large multifunctional polypeptide that initiates and controls the de novo biosynthesis of pyrimidines in animals. In this issue of Structure, Grande-García and colleagues provide the first atomic information of this antitumoral target by reporting the crystal structure of the dihydroorotase domain of human CAD.

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Keywords

Structural Biology, Aspartate Carbamoyltransferase, Humans, Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing), Molecular Biology, Dihydroorotase

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