Brown adipose tissue (BAT) is the main site for adaptive heat production through non-shivering thermogenesis. BAT has been brought to attention, since it provides a protective mechanism against excessive body weight and fat mass accumulation. Recently, it has been suggested emerging roles of BAT activation in the regulation of metabolism, including control of triglyceride clearance, glucose homeostasis and insulin sensitivity. In this context, Maresin1 (MaR1) is a specialized proresolving lipid mediator derived from DHA with insulin-sensitizing properties in obese mice. The aim of the present study was to elucidate whether MaR1 could activate brown adipocytes, which may be involved in its insulin-sensitizing actions. Thus, MaR1 eff ects were tested in murine brown adipocytes. MaR1 treatment (24h) increased UCP1 protein content and upregulated thermogenic and mitochondrial biogenesis genes (Tfam, Nrf1, Pgc1a, Ucp1, Gpr120 and Fgf21), as well as the oxygen consumption rate. These effects were accompanied with increased glucose uptake and upregulation of Glut4 mRNA, and with a stimulation of both fatty acid uptake and oxidation and increased expression of Cpt1a and Acox1. Taken together, all these results strongly suggest the ability of MaR1 to activate brown adipocytes, and subsequently, fat-burning and improve glucose homeostasis. MaR1 could be a promising therapeutic molecule to counteract obesity and type 2 diabetes.

Resumen del póster presentado al 1st Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies y al XL Spanish Society of Biochemistry and Molecular Biology (SEBBM) Congress, celebrado en Barcelona (España) del 23 al 26 de octubre de 2017.-- et al.

Peer reviewed