N-substituted phthalimides exhibit different biological activities depending on the substitution. Such as, anticancer activity and germination stimulant. The stimulatory activity represents a similar behavior as gibberellins. Gibberellins are terpenic plant hormones with germination and stimulatory activity towards different growth steps in different plant species. In the same manner, strigolactones are plant hormones and natural promotors of parasitic weeds germination. They are formed with a typical ring structure sequence ABCD. The D ring is a lactone and has been found to be essential for their biological activity. Recently, we introduced a lactone moiety to phthalimides and performed the germination of parasitic weeds with a family of compounds we ca lled phthalimide-lactones. A lactone ring have been found previously partly responsible for the cytotoxic and anti-flammatory activity of sesquiterpene lactones. Lastly, we have introduced different modifications in gibberellic acid, including a lactone ring, to obtain new active compounds in a new strategy. The aim of this project is to obtain multifunctional compounds that stimulate parasitic weeds. The preliminary results are promising, we have phthalimide-lactones that are stimulants of different species of parasitic weeds at high levels. Our current resu lts on phthalimides and gibberellin derivatives are presented and discussed.

Trabajo presentado en el COST Action FA1206 (WG1, WG2 y WG3 meetings), celebrado en Bucarest del 15 al 18 de septiembre de 2015.

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