Syntesis of tetrodotoxin, its analogues and intermediates thereof

The invention provides for the synthesis of Tetrodotoxin, its tautomers, enantiomers, distercoisomer or analogues through the use of spirolactam compounds of formula II as starting material, by incorporation of a guanidine (or similar) residue to a compound of formula II prior to the formation of an orthoester, or the use of a compound of formula VII as starting material.

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Laboratorios del Dr. Esteve S.A.

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