
pmid: 26093986
handle: 10261/154398
We read with great interest the article by Dadras et al in The American Journal of Pathology describing microphthalmia-associated transcription factor (MITF) as a regulator of pigment epithelium-derived factor (PEDF) in human melanoma. Although we are pleased to see that the authors have confirmed our recent results, we feel that the authors overlooked a careful review of the concurrent literature on the biological role of PEDF during melanoma progression and the identification of MITF as a transcriptional regulator of PEDF.
Supported by Ministerio de Ciencia y Competitividad of Spain grant SAF-2011-24225.
Peer Reviewed
Gene Expression Regulation, Neoplastic, Male, Microphthalmia-Associated Transcription Factor, Skin Neoplasms, Animals, Humans, Female, Nerve Growth Factors, Eye Proteins, Melanoma, Serpins
Gene Expression Regulation, Neoplastic, Male, Microphthalmia-Associated Transcription Factor, Skin Neoplasms, Animals, Humans, Female, Nerve Growth Factors, Eye Proteins, Melanoma, Serpins
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