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Microphthalmia-Associated Transcription Factor: A Central Regulator of Pigment Epithelium-Derived Factor Controlling Human Melanoma Progression.

Authors: Jiménez, Benilde; Fernández-Barral, Asunción; Orgaz, José L.;

Microphthalmia-Associated Transcription Factor: A Central Regulator of Pigment Epithelium-Derived Factor Controlling Human Melanoma Progression.

Abstract

We read with great interest the article by Dadras et al in The American Journal of Pathology describing microphthalmia-associated transcription factor (MITF) as a regulator of pigment epithelium-derived factor (PEDF) in human melanoma. Although we are pleased to see that the authors have confirmed our recent results, we feel that the authors overlooked a careful review of the concurrent literature on the biological role of PEDF during melanoma progression and the identification of MITF as a transcriptional regulator of PEDF.

Supported by Ministerio de Ciencia y Competitividad of Spain grant SAF-2011-24225.

Peer Reviewed

Keywords

Gene Expression Regulation, Neoplastic, Male, Microphthalmia-Associated Transcription Factor, Skin Neoplasms, Animals, Humans, Female, Nerve Growth Factors, Eye Proteins, Melanoma, Serpins

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green