Brief Report: Differential Effects of Tenofovir, Abacavir, Emtricitabine, and Darunavir on Telomerase Activity In Vitro

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2017 Spain English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:JAIDS Journal of Acquired Immune Deficiency Syndromes, volume 74, pages 91-94 (issn: 1525-4135,

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Authors: Natalia, Stella-Ascariz; Rocío, Montejano; Laura, Pintado-Berninches; Susana, Monge; José I, Bernardino; Ignacio, Pérez-Valero; María L, Montes; +3 Authors

doi: 10.1097/qai.0000000000001154

pmid: 27552152

handle: 10261/150723

Brief Report: Differential Effects of Tenofovir, Abacavir, Emtricitabine, and Darunavir on Telomerase Activity In Vitro

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Abstract

Abstract: In vitro, tenofovir and abacavir induced a significant dose-dependent inhibition of telomerase activity at therapeutic concentrations in peripheral blood mononuclear cells of healthy subjects. Median inhibition of telomerase activity by tenofovir at 0.5 and 1 μM was 29% [Interquartile range (IQR) 29%–34%, P = 0.042] and 28% (IQR 28%–41%, P = 0.042), respectively. Abacavir inhibition was 12% (IQR 9%–13%, P = 0.043) at 3 μM and 14% (IQR 10%–29%, P = 0.043) at 10 μM. Tenofovir and abacavir did not change human telomerase reverse transcriptase (hTERT) levels or mRNA levels of other telomerase complex genes. Exposure to emtricitabine or darunavir did not affect telomerase activity, hTERT protein levels, or mRNA levels of telomerase/shelterin genes.

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Spain

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Keywords

Leukocytes, Mononuclear, Humans, Reverse Transcriptase Inhibitors, HIV Protease Inhibitors, Telomere, HIV infection, hTERT, Telomerase, Healthy Volunteers, Antiretroviral therapy

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