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Boophilus microplus: Aspectos biológicos y moleculares de la resistencia a los acaricidas y su impacto en la salud animal

Authors: Delia Inés Domínguez-García; Rodrigo Rosario-Cruz; Consuelo Almazán-García; Jorge Alberto Saltijeral Oaxaca; José De la Fuente;

Boophilus microplus: Aspectos biológicos y moleculares de la resistencia a los acaricidas y su impacto en la salud animal

Abstract

[ES]: La aplicación de ixodicidas durante mucho tiempo ha sido la alternativa de elección para el control de la garrapata Boophilus microplus, sin embargo, actualmente el uso de los ixodicidas tiene una eficacia limitada en la reducción de las infestaciones debido al desarrollo de poblaciones de garrapatas resistes. La resistencia a ixodicidas es un problema creciente que necesita ser atendido, por que en este momento está afectando la competitividad de la ganadería y la economía de miles de productores en México. La solución de este problema requiere de la implementación de programas de investigación que coadyuven a dilucidar los mecanismos moleculares de la resistencia con el fin de encontrar nuevos blancos moleculares para el diagnóstico y para el desarrollo de vacunas recombinantes. El uso reciente de nuevas herramientas genómicas y los enfoques de genética reversa, son una extraordinaria herramienta que podría ayudar en el descubrimiento de nuevos genes de interés diagnóstico ó imunoprofiláctico, contribuyendo así al mejoramiento de las estrategias de control de garrapatas y los programas de mitigación de la resistencia a ixodicidas. El propósito de esta revisión es compilar diferentes tópicos actuales relacionados con la biología de las garrapatas, resistencia a los ixodicidas, y las perspectivas de la investigación genómica en la garrapata Boophilus microplus, iniciando con algunas consideraciones biológicas y moleculares acerca de la nueva clasificación de este ectoparásito, hasta el análisis de la resistencia a los ixodicidas, su impacto en la industria ganadera en México y la aplicación de la genómica en la solución de problemas asociados con el control de las garrapatas mediante el diseño de nuevos métodos diagnósticos así como el desarrollo de vacunas contra garrapatas.

[EN]: The application of Ixodicides has been considered for a long time the alternative for control of the cattle tick Boophilus microplus, however, its use is currently limited in reducing tick infestations, due to the appearance of resistant field tick populations. Ixodicide resistance is a growing problem that needs to be attended, because, it is currently affecting the competitiveness of the Mexican cattle industry in general and in particular the income of cattle producers. The solution to this problem needs to increase the budget dedicated to basic research in order to elucidate the molecular mechanisms of ixodicide resistance leading to the discovery of new molecular targets for ixodicide resistance detection and recombinant vaccine development. The recent use of new genomic tools, as well as reverse genetics approaches, will provide an extraordinary contribution to the improvement of tick control strategies and ixodicide resistance mitigation programs. The aim of the present review is to make a compilation of different topics related with acaricide resistance in the cattle tick Boophilus microplus, starting with some biological and molecular considerations on its new classification, to the analysis of ixodicide resistance, its impact on the Mexican cattle industry and the perspective of the genomic research in order to solve the problems associated to tick control, new diagnostic tools and development of tick vaccines.

Al Consejo Nacional de Ciencia y Tecnología por la beca otorgada a la MC Delia Inés Domínguez García inscrita en el programa doctoral de Ciencias Biológicas y de la Salud de la Universidad Autónoma Metropolitana. Este trabajo fue parcialmente financiado por el proyecto 90195 del programa de CONACYT de apoyos complementarios otorgado a Dr. Rodrigo Rosario Cruz.

Peer Reviewed

Keywords

boophilus microplus, Ticks, Boophilus microplus, Resistencia, Garrapatas, Resistance, Agrociencias, Pesticides, resistencia, pesticidas, Pesticidas

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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