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Insights on the health benefits of the bioactive compounds of coffee silverskin extract

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2016 English Publisher:Elsevier BVJournal:Journal of Functional Foods, volume 25, pages 197-207 (issn: 1756-4646,

Authors: Miguel Herrero; María Dolores del Castillo; Miryam Amigo-Benavent; Miryam Amigo-Benavent; María Ángeles Martín; María D. Mesa; Adriana Lezama; +2 Authors

doi: 10.1016/j.jff.2016.06.001

handle: 10668/18815 , 10261/140285

Insights on the health benefits of the bioactive compounds of coffee silverskin extract

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Abstract

The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.

Related Organizations

National Research Council
Italy
Spanish National Research Council
Spain
Instituto de Investigación Biosanitaria
Spain
Institute of Food Science
Italy
University of Granada (UGR)
Spain

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Keywords

Niacinamide, Cells, Diabetes Mellitus tipo 2, Biological Availability, Bioaccessibility, Antioxidantes, Disponibilidad biológica, Antioxidants, In-vitro, Caffeine, Animals, TX341-641, Coffee silverskin, Niacinamida, Pancreas, Tracto gastrointestinal, Nutrition. Foods and food supply, Streptozotocin, Proteins, Chlorogenic acid, Type 2 diabetes, Gastrointestinal digestion, Hydrogen-Ion Concentration, Antioxidant capacity, Rats, Gastrointestinal Tract, Metabolism, Concentración de iones de Hidrógeno, Páncreas, Diabetes Mellitus, Type 2, Oxidative stress, Digestión, Animales, Proteínas, Chlorogenic acids, Digestion

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