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RNA
Article
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DIGITAL.CSIC
Article . 2009 . Peer-reviewed
Data sources: DIGITAL.CSIC
RNA
Article . 2009 . Peer-reviewed
Data sources: Crossref
RNA
Article . 2009
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The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers

Authors: Briones, Carlos; Stich, Michael; Manrubia Cuevas, Susanna;

The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers

Abstract

A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered.

Country
Spain
Keywords

Structural motif, Hairpin ribozyme, Inverted Repeat Sequences, Origin of Life, Evolution, Molecular, RNA polymerase, RNA ligation, Nucleic Acid Conformation, RNA folding, Modular evolution, RNA, Catalytic

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
95
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Top 10%
38
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bronze