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Re-designing the substrate binding pocket of laccase for enhanced oxidation of sinapic acid

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2016 Spain, Spain, Italy English Publisher:Royal Society of Chemistry (RSC)Journal:Catalysis Science & Technology, volume 6, pages 3,900-3,910 (issn: 2044-4753, eissn: 2044-4761, Copyright policy )Funded by:EC | INDOX
Authors: Pardo, Isabel; Santiago, Gerard; GENTILI, Patrizia; Lucas, Fatima; Monza, Emanuele; Medrano, Francisco Javier; GALLI, Carlo; +3 Authors

doi: 10.1039/c5cy01725d

handle: 10261/133434 , 2117/84199 , 20.500.14243/324165 , 11573/843424

Re-designing the substrate binding pocket of laccase for enhanced oxidation of sinapic acid

Abstract

Iterative saturation mutagenesis was performed over six residues delimiting the substrate binding pocket of a high redox potential chimeric laccase with the aim of enhancing its activity over sinapic acid, a lignin-related phenol of industrial interest.

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Keywords

Sinapic acid, Iterative saturation mutagenesis, :Enginyeria mecànica::Impacte ambiental [Àrees temàtiques de la UPC], Laccase, oxidations, Oxidation--Measurement, Molecular dynamics, Enhanced oxidation, active site, binding modes, laccase; trametes; purified laccase, Àrees temàtiques de la UPC::Enginyeria mecànica::Impacte ambiental, Dinàmica molecular, mutagenesis

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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