
handle: 10261/127970
En esta tesis se ha descrito el uso de nanoprismas de oro para de forma eficiente y selectiva inducir apoptosis en celulas tumorales y mas importante, descifrar el mecanismo de muerte celular que se desencadena, para poder predecir la eficacia de la terapia fototermica usando nanoprismas de oro contra celulas tumorales que son resistentes a las terpias convencionales. Ademas se ha llevado a cabo un estudio en detalle de la toxicidad de los nanoprismas de oro in vitro asi como de su toxicidad y biodistribución in vivo para poder prevenir y minimizar posibles efectos adversos.
Tesis llevada a cabo para conseguir el grado de doctor en la Universidad de Zaragoza en enero de 2016.-- Sobresaliente "Cum Laude".
Peer reviewed
Terapia fototérmica, Nanoprismas oro, Apoptosis, Toxicidad, Seguridad
Terapia fototérmica, Nanoprismas oro, Apoptosis, Toxicidad, Seguridad
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