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handle: 10261/125197
[ES] La presente invención se encuadra dentro del campo de la biotecnología. En la presente invención se presenta una secuencia polipeptídica derivada del módulo de unión a pared del enzima lítica del fago Cp7 (Cpl-7), que permite la construcción de nuevas enzimas líticas con actividad bactericida mejorada y amplio espectro. Igualmente, en esta invención se incluyen enzimas quiméricas que contienen dicho módulo de unión a pared mejorado y se dan ejemplos de su actividad frente a especies Gram-positivas y Gram-negativas.
[EN] The invention relates to the field of biotechnology and concerns a polypeptide sequence derived from the Cp7 phage lytic enzyme wall-binding module (Cpl-7), which enables new lytic enzymes having improved bactericidal activity and a broad spectrum to be built. The invention also concerns chimeric enzymes containing the improved wall-binding module, and examples of the activity thereof against gram positive and gram negative species are provided.
Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Red
A1 Solicitud de patente con informe sobre el estado de la técnica
Peer reviewed
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