Effect of PARP Inhibitors on TRAIL-induced cell death in gliobastoma cell lines
Effect of PARP Inhibitors on TRAIL-induced cell death in gliobastoma cell lines
TRAIL (Tumor necrosis factor‐related apoptosis‐inducing ligand) has been proved to be an effective anti‐neoplastic agent in pre‐clinical trials. However, cells from Glioblastoma (GBM, most common and lethal brain tumor) are resistant to this therapy. Therefore, the research of new combined therapies which enhance the effect of TRAIL could probably offer an interesting alternative option. PARP1 has been shown to modify and inactivate DISC components impairing TRAIL‐induced cell death.
This work was supported (in part) by a grant (RD12/0036/0026) from Red Temática de Investigación Cooperativa en Cáncer (RTICC), Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness & European Regional Development Fund (ERDF) “Una manera de hacer Europa"
Póster presentado en la VII Reunión Anual de la Red Temática de Investigación Cooperativa en Cáncer (RTICC), celebrada en Salamanca el 24 de septiembre de 2014
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