Name: Solid-phase peptide synthesis using N-alpha-trityl-amino acids
Keywords: Solid phase peptide synthesis, Amino acid derivatives, Amino protection, N-trityl-amino acids, Protecting Group

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2002Publisher:Kluwer Academic Publishers

Authors: Eritja Casadellà, Ramón; Albericio, Fernando; Marcos, Miguel Ángel; García de la Torre, Beatriz;

handle: 10261/122938

Solid-phase peptide synthesis using N-alpha-trityl-amino acids

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Abstract

The preparation of Nα-trityl-amino acids is described. Several derivatives of trifunctional amino acids carrying acid- and base-labile side-chain protecting groups and the trityl group at the Nα position are prepared for first time. The incorporation of Nαtrityl-amino acids into peptide sequences using solid-phase protocols was achieved. The use of the trityl group for the protection of the α-amino group in conjunction with base-labile side-chain protecting groups constitutes a new method for the assembly of peptides in mild conditions.

We thank the Dirección General de Investigación Científica y Técnica (projects BQU2000-0649 and BQU2000-0235) and the Generalitat de Catalunya (project 2000-SGR-0018) for financial support.

Peer reviewed

Related Organizations

Spanish National Research Council
Spain

Keywords

Solid phase peptide synthesis, Amino acid derivatives, Amino protection, N-trityl-amino acids, Protecting Group

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