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Recolector de Ciencia Abierta, RECOLECTA
Doctoral thesis . 2014
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Doctoral thesis . 2015 . Peer-reviewed
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Esteorosis aórtica calcificada y proteínas de la matriz extracelular

Authors: Castaños-Mallor Morcillo, Irene;

Esteorosis aórtica calcificada y proteínas de la matriz extracelular

Abstract

En condiciones basales, el colágeno XIII se expresa sobre la superficie celular de células AVIC, aunque la mayor parte de esta proteína se encuentra localizada a nivel intracelular. 2. En AVIC control, la activación del receptor TLR3 con Poly I:C aumenta de modo significativo la expresión de colágeno XIII en la cara externa de la membrana extracelular, pero no su expresión a nivel intracelular. 3. En AVIC estenóticas el colágeno XIII se expresa sobre la superficie celular, aunque la mayor parte de esta proteína se encuentra localizada a nivel intracelular, y su expresión se induce por la activación de TLR3. 4. En cuanto a la comparación entre AVIC estenóticas y controles, en condiciones basales se observa un aumento de la expresión de colágeno XIII, aunque el efecto no es estadísticamente significativo, en células estenóticas con respecto a las controles

Instituto de Biologí­a y Genética Molecular (IBGM)

Máster en Investigación Biomédica

Keywords

Estenosis aórtica calcificada - Tratamiento

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