Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2012 Spain English Publisher:Elsevier BVJournal:Modern Pathology, volume 25, pages 1,637-1,643 (issn: 0893-3952,

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Authors: Dorfman, David M.; Shahsafaei, Aliakbar; Alonso, Miguel A.;

doi: 10.1038/modpathol.2012.129

pmid: 22899296

handle: 10261/115315

Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

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Abstract

CD200, an immunoglobulin superfamily membrane glycoprotein, is expressed in a number of B cell lymphoproliferative disorders, including primary mediastinal large B cell lymphoma, but not diffuse large B cell lymphoma, based on a preliminary study. Here, we compare the expression of CD200 with other markers of primary mediastinal large B cell lymphoma, including MAL and CD23, in formalin-fixed, paraffin-embedded histologic sections from a series of 35 cases of primary mediastinal large B cell lymphoma and 30 cases of diffuse large B cell lymphoma. CD200 exhibits the greatest staining sensitivity of the markers studied: 94%, compared with CD23 (69%), MAL (86%), TRAF (86%), and REL (77%). It exhibits staining specificity of 93%, similar to that of CD23 (93%) and MAL (97%), and greater than that of TRAF (77%) and REL (83%). We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma.

Country

Spain

Related Organizations

Centro de Biología Molecular Severo Ochoa
Spain
Spanish National Research Council
Spain
Harvard University
United States
Brigham and Women's Faulkner Hospital
United States
Autonomous University of Madrid
Spain

Keywords

Adult, Male, Receptors, IgE, Myelin and Lymphocyte-Associated Proteolipid Proteins, Diffuse large B cell lymphoma, Middle Aged, Immunohistochemistry, Mediastinal Neoplasms, Proto-Oncogene Proteins c-rel, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, Young Adult, REL, Antigens, CD, TRAF, Biomarkers, Tumor, Humans, Female, Lymphoma, Large B-Cell, Diffuse, Aged

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