Genomic localization of hepatitis B virus in a human hepatoma cell line

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1986 English Publisher:Oxford University Press (OUP)Journal:Nucleic Acids Research, volume 14, pages 8,373-8,386 (issn: 0305-1048, eissn: 1362-4962,

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Authors: Zerial, Marino; Salinas, Julio; Filipski, J.; Bernardi, G.;

doi: 10.1093/nar/14.21.8373

pmid: 3024104

pmc: PMC311865

handle: 10261/112055

Genomic localization of hepatitis B virus in a human hepatoma cell line

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Abstract

The integration of hepatitis B viral sequences in the human hepatoma Alexander cell line has been investigated after fractionation of the cell line DNA by centrifugation in a Cs2SO4/BAMD (3,6-(bis-acetato mercurimethyl) dioxane) density gradient. Eight out of nine integrated viral sequences were localized in DNA component H3, which only represents 4% of the human genome and matches the base composition of HBV sequences. These results indicate a targeting and/or a higher stability of the latter in a specific, small compartment of the host genome.

Keywords

Hepatitis B virus, Carcinoma, Hepatocellular, DNA, Viral, Liver Neoplasms, Humans, Nucleic Acid Hybridization, DNA Restriction Enzymes, DNA, Neoplasm, Cell Line

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