All4312, an NtcA-regulated two-component response regulator inAnabaenasp. strain PCC 7120

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2006 Spain English Publisher:Oxford University Press (OUP)Journal:FEMS Microbiology Letters, volume 256, pages 171-177 (issn: 0378-1097, eissn: 1574-6968,

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Authors: Muro Pastor, Alicia María; Flores García, Enrique; Olmedo Verd, Elvira de;

doi: 10.1111/j.1574-6968.2006.00136.x

pmid: 16487336

handle: 11441/69282 , 10261/109787

All4312, an NtcA-regulated two-component response regulator inAnabaenasp. strain PCC 7120

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Abstract

All4312, encoded by open reading frame all4312 in the genome of the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120, exhibits a CheY-like receiver domain and an output domain similar to that of OmpR, characteristic of two-component response regulators. Expression of all4312 was directly regulated by NtcA, the global transcriptional regulator of nitrogen assimilation in cyanobacteria. Features characteristic of NtcA-activated promoters were also found upstream from genes encoding All4312 homologues in several other cyanobacterial genomes. Expression of all4312 was however unaffected in a mutant of hetR, which encodes a regulator triggering heterocyst development. The function of All4312 may be related to the cellular response to nitrogen deprivation.

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Keywords

Nitrogen, Recombinant Fusion Proteins, Green Fluorescent Proteins, Gene Expression, Electrophoretic Mobility Shift Assay, Ammonium Chloride, Bacterial Proteins, Promoter Regions, Genetic, Gene Expression Regulation, Bacterial, Blotting, Northern, Anabaena ntcA,, Anabaena, Response regulator, Culture Media, DNA-Binding Proteins, ntcA, Two-component, Two-component all4312, Mutation, Trans-Activators, all4312, Sequence Alignment, Plasmids, Transcription Factors

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