Method for obtaining useful information for the diagnosis of neuromuscular diseases. The invention describes a method for obtaining, on the basis of a patient biopsy, new parameters that allow objective diagnosis of different neuromuscular diseases and the degree to which these affect the patient, comprising: -staining the biopsy sample in order to highlight type-I muscle fibres, type-II muscle fibres and endomysium; - obtaining an image of the biopsy sample after staining; - dividing the image into segments to identify the outlines of the muscle fibres; - forming a network in which the muscle fibres constitute nodes and the contacts between muscle fibres constitute the connections between the nodes; - forming a vector characteristic of the biopsy sample, the elements of which are chosen from geometric parameters of the fibres and parameters of the network constructed; - and comparing control and affected biopsy samples by means of ACP using, in each case, the characteristic vector selected.

Servicio Andaluz de Salud, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (España)

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Peer reviewed