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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Research Repository ...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Recolector de Ciencia Abierta, RECOLECTA
Bachelor thesis . 2022
License: CC BY NC ND
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Tumor-on-a-chip: new strategies of in-vitro cancer cell culture

Authors: Cànaves Llabrés, Antoni Ignasi;

Tumor-on-a-chip: new strategies of in-vitro cancer cell culture

Abstract

Aquest projecte proposa un marc per crear dispositius microfluídics per al cultiu cel·lular, inspirats en organ-on-a-chip i tumor-on-a-chip i fabricats en gran part amb la fabricació de filaments fusionats. Aquesta tecnologia única promet simplificar i minimitzar els costos de fabricació, facilitar l'adaptació dels xips de cultiu a l'aplicació actual, ser estanca, tenir un flux ajustable, sense cables i servir com a plataforma per a futurs dissenys bio-inspirats. Perquè els models funcionin malgrat el factor de miniaturització requerit, es van ajustar les mides dels diferents components i seccions mitjançant proves d'esforç. Per segellar les peces i garantir que el sistema fos impermeable, es va utilitzar el cloroform; també es va utilitzar per afavorir l'adhesió de les capes (i, per tant, la força) i per suavitzar la textura de les peces per reduir l'adhesió cel·lular. PLA, PETG i PCTG s'utilitzen per fabricar la majoria dels models, el TPU s'utilitza per al sistema de filtratge. Els taps de PMMA per als xips s'han de fer abans de les proves de cultiu per controlar amb precisió les cèl·lules. Aquests es tallaran amb un tallador làser i s'uniran amb cloroform. El cultiu cel·lular i les proves de viabilitat determinaran l'eficàcia i el potencial futur del dispositiu

This project proposes a framework for creating microfluidic devices for cell culture, inspired by organ-on-a-chip and tumor-on-a-chip and manufactured largely with fused filament fabrication. This unique technology promises to simplify and minimise manufacturing costs, make it easier to adapt culture chips to the current application, be watertight, have an adjustable flow, be wire-free, and serve as a platform for future bio-inspired designs. To make the models work despite the required miniaturisation factor, the sizes of the various components and sections were adjusted using stress testing. To seal the parts and ensure that the system was impermeable, chloroform was used; it was also used to promote layer adhesion (and hence strength) and to smooth the pieces' texture to reduce cell adhesion. PLA, PETG, and PCTG are utilised to manufacture the majority of the models, TPU is used for the filtering system. PMMA caps for the chips must be made before culture tests to precisely monitor cells. These will be cut with a laser cutter and joined with chloroform. Cell culture and viability testing will determine the device's efficacy and future potential

Country
Spain
Related Organizations
Keywords

Breast -- Cancer -- Treatment -- Research, Pulmons -- Càncer -- Tractament -- Investigació, Lungs -- Cancer -- Treatment -- Research, Mama -- Càncer -- Tractament -- Investigació, Cèl·lules canceroses -- Cultiu in vitro, Cancer cells -- Micropropagation

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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