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Semina: Ciências Agrárias
Article . 2017
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Ulcerative dermatitis caused by feline herpesvirus type 1 in a domestic cat

Authors: Argenta, Fernando Froner; Ramos, Bárbara Carolina; Fredo, Gabriela; Laisse, Cláudio João Mourão; Rolim, Veronica Machado; Cargnelutti, Juliana Felipetto; Flores, Eduardo Furtado; +3 Authors

Ulcerative dermatitis caused by feline herpesvirus type 1 in a domestic cat

Abstract

A case of ulcerative dermatitis caused by feline herpesvirus type 1 (FeHV-1) in an adult male domestic shorthair cat is reported. The cat was rescued from the streets and presented with ulcerative lesions at the nasal planum and tongue in addition to a history of occasional sneezing. Thirty days after of the first clinical evaluation, the cat died as a result of acute myeloid leukemia. During necropsy, ulcerative lesions were found on the superior lip, the skin of the nasal planum, and at the periorbital region. Ulcerations were also noted on the tongue and hard palate. Histological examination revealed extensive epidermal necrosis, which involved the subjacent dermis and adnexal structures; the inflammatory infiltrate consisted of neutrophils, mast cells, and lymphocytes. Amphophilic intranuclear inclusion bodies were occasionally observed in intact epithelial cells. In the immunohistochemical evaluation, positive intracytoplasmic immunolabeling was detected in the sebaceous and follicular epithelial cells as well as in the bronchiolar epithelial cells. Samples of lymphoid tissue tested positive for the presence of feline leukemia virus and feline immunodeficiency virus by immunohistochemistry. Pulmonary tissue fragments were immunolabeled for feline calicivirus. Samples obtained from a cutaneous lesion were subjected to virus isolation in a cellular culture, which revealed the cytopathic effects characteristic of herpesvirus. FeHV-1 was detected in the samples by polymerase chain reaction.

Descreve-se um caso de dermatite ulcerativa causada por herpesvírus felino tipo 1 (FeHV-1), em um gato adulto, macho, sem raça definida. O gato foi resgatado da rua e apresentava uma lesão ulcerativa no plano nasal e língua, além de espirros esporádicos. Trinta dias após o primeiro atendimento, o gato morreu por leucemia mieloide aguda. Na necropsia, o lábio superior e a pele do plano nasal e periorbital apresentaram extensa lesão ulcerativa, além de ulcerações na língua e no palato duro. Histologicamente havia extensa necrose da epiderme, estendendo-se à derme subjacente e estruturas anexas, associada ao infiltrado inflamatório, constituído por neutrófilos, mastócitos e linfócitos. Observaram-se ainda, ocasionalmente, em células epiteliais intactas, corpúsculos de inclusão intranucleares anfofílicos. Na avaliação imuno-histoquímica anti-FeHV-1 observou-se imunomarcação positiva intracitoplasmática nas células epiteliais e nas células epiteliais bronquiolares. Amostras de tecido linfoide apresentaram imunomarcação para vírus da leucemia felina, vírus da imunodeficiência felina, além de marcação para calicivírus em fragmentos pulmonares. Fragmentos da lesão cutânea foram submetidos a isolamento viral em cultivo celular, onde foi observado efeito citopático característico de herpesvírus e a amostra foi positiva na PCR para FeHV-1.

Keywords

Pele, Herpesvirus felino tipo 1, Agriculture (General), Vírus da imunodeficiência felina, Dermatite, Herpesvirus, Felino, Immunohistochemistry, S1-972, Feline, Gatos, Dermatite viral, PCR, Virus isolation, Isolamento viral., Imuno-histoquímica, Herpesvírus, Leucemia felina, Viral dermatitis, Skin

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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