Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ LAReferencia - Red F...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
addClaim

Carcinoma Hepatocelular manejo cirúrgico atual

Authors: Chedid, Aljamir Duarte; Chedid, Márcio Fernandes;

Carcinoma Hepatocelular manejo cirúrgico atual

Abstract

Esta é uma revisão sobre o manejo cirúrgico do carcinoma hepatocelular, complicação freqüente e importante da cirrose hepática, e que é considerado, atualmente, uma doença pré-maligna. A hepatite B e a hepatite C crônica também são fatores de risco impor tantes. Com cerca de 5 cm de tamanho, o nódulo regenerativo passa a perder diferenciação e a demonstrar invasão vascular microscópica. Apenas cerca de 15% dos carcinomas hepatocelulares são passíveis de intervenção cirúrgica potencialmente curativa no momento do diagnóstico. O diagnóstico diferencial com outros tumores hepáticos é efetuado através da fase ar terial da tomografia computadorizada. O único tratamento potencialmente curativo para carcinoma hepatocelular, atualmente, é a ressecção do tumor, seja esta realizada através de hepatectomia parcial ou de hepatectomia total com transplante hepático. Pacientes portadores de cirrose hepática Child C não devem ser submetidos a ressecção hepática parcial. Para estes, as opções terapêuticas restringem-se apenas ao transplante hepático quando selecionáveis. Atualmente, os pacientes cirróticos por tadores de hepatocarcinoma podem ser transplantados desde que tenham lesão única com até 5 cm ou até três lesões de, no máximo, 3 cm cada. A sobrevida em 5 anos para pacientes transplantados pode alcançar 70%.

This review focuses on the surgical management of the hepatocellular carcinoma, an impor tant complication of hepatic cirrhosis. Therefore, hepatic cirrhosis must be thought as a pre-malignant disease. B hepatitis and C chronic hepatitis are also important risk factors. When it reaches around 5 cm of diameter, the regenerative nodule begins to loose dif ferentiation and to invade vessels. Only 15% of the diagnosed hepatocellular carcinomas may be surgically resected with curative criteria. Dif ferential diagnosis with other hepatic tumors is made by ar terial phase of computed tomography. The only potentially curative treatment to hepatocellular carcinoma is surgery. This could be per formed by par tial hepatic resection or total hepatic resection followed by hepatic transplantation. Child C cirrhotic patients should not be submitted to a partial hepatic resection. The only available treatment for them is hepatic transplantation. Presently, cirrhotic patients with hepatocellular carcinoma could be submitted to liver transplantation only if they have a single nodule of less than 5 cm of diameter or if they have up to three nodules of less than 3 cm of diameter each. The 5-year survival period of patients that underwent a liver transplantation may be as high as 70%.

Keywords

Transplantation, Hepatocellular carcinoma, Transplante, Hepatectomia, Carcinoma hepatocelular, Hepatic resection

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities