
handle: 10171/36412
This article reviews the most useful animal models of Parkinson's disease available. Basically they include the model of unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA) in rodents and the 1-methy-4-phenyl-1,2,3,6, tetrahydropyridine (MPTP) model of parkinsonism in non-human primates. The major neurochemical and histological alterations found in these two models are also analyzed. Finally, possible applications of these models of parkinsonism are also discussed.
Enfermedad de Parkinson, 1-metil-4-fenil,1,2,3,6 tetrahidropiridina, 6-hidroxidopamina, Neurología
Enfermedad de Parkinson, 1-metil-4-fenil,1,2,3,6 tetrahidropiridina, 6-hidroxidopamina, Neurología
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