In most hospitals, the results of countless cultures and sensitivities are summarized and reported in the form of antibiograms. The advantages and limitations of antibiograms must be considered when contemplating empiric therapeutic recommendations. Methods to optimally utilize this resource are described. Antibiograms may also be used to guide formulary decisions, although practically they are more useful in monitoring recent additions or deletions. Antibiograms that incorporate formulary, drug of choice, dosage, cost, and hospital-specific restrictions will facilitate patient-specific decisions.