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IgA-nefropatia

Authors: Soro-Paavonen, Aino; Kaartinen, Kati;
Abstract

IgA-nefropatia on maailman yleisin primaarinen glomerulonefriitti eli munuaiskerästulehdus. Potilaalla on useimmiten lievä proteinuria ja hematuria yhdistyneenä kohonneeseen verenpaineeseen. Hoidon perustana ovat proteinuriaa estävä verenpainelääkitys angiotensiinireseptorin (ATR) salpaajalla tai angiotensiinikonvertaasin (ACE) estäjällä, dyslipidemian hoito ja elintapamuutokset. Kansainvälisessä asiantuntijapaneelissa 2021 korostettiin elintapaintervention ja proteinuriaa vähentävän lääkityksen merkitystä. Sairauden ennusteen arvioinnissa voidaan hyödyntää kansainvälistä IgA-riskilaskuria. Natriumin- ja glukoosinkuljettajaproteiini 2:n (SGLT-2) estäjälääkitys vaikuttaa lupaavalta lisältä vähentämään proteinuriaa ja hidastamaan glomerulusten suodatusnopeuden (GFR) pienenemistä. SGLT-2:n estäjistä dapagliflotsiini ja empagliflotsiini on jo hyväksytty kroonisen munuaissairauden hoitoon. Tietoa tämän lääkeryhmän käytettävyydestä IgA-nefropatian hoidossa saataneen pian lisää.

Country
Finland
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Keywords

+drug therapy, Immunosuppression Therapy, Hypertension, Renal, +diagnosis, Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet, Glomerulonephritis, IGA, Risk Assessment, Proteinuria, +therapy, +prevention & control, +classification, Glucocorticoids, Hematuria, Glomerular Filtration Rate

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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