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Review . 2022 . Peer-reviewed
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DPYD-geenitestaus kliinisessä käytössä

descriptionPublicationkeyboard_double_arrow_right Review 01 Jan 2021 Finland Publisher:Laaketieteellinen Aikakauskirja DuodecimJournal:Duodecim, volume 137, pages 2,560-2,566 (issn: 0012-7183, Copyright policy )
Authors: Saarenheimo, Jatta; Wahid, Nesna; Tornio, Aleksi; Ristamäki, Raija; Keinänen, Mauri; Niemi, Mikko; Turpeinen, Miia; +1 Authors

handle: 10138/352420

DPYD-geenitestaus kliinisessä käytössä

Abstract

Eri syöpien hoidossa laajasti käytettyihin fluoropyrimidiini-lääkkeisiin (kapesitabiini, tegafuuri ja 5-fluorourasiili) liittyy vakavien haittavaikutusten mahdollisuus. Niistä tyypillisimpiä ovat ripuli, suun ja suolen limakalvojen haavaumat, luuydinlama, hermotoksisuus sekä sydänhaitat. Yksi syy haittoihin on dihydropyrimidiinidehydrogenaasi-entsyymin (DPD) vajaus ja toimimattomuus, joka johtaa fluorourasiilin aineenvaihduntahäiriöön ja kertymiseen elimistöön. Vuonna 2020 Euroopan lääkevirasto (EMA) antoi suosituksen, jonka mukaan DPD-entsyymin toimimattomuus tulee selvittää ennen fluoropyrimidiinien antamista. Testaus voidaan tehdä tutkimalla potilaan verinäytteestä tunnettuja kliinisesti merkittäviä DPYD-geenivariantteja. Fluoropyrimidiinejä ei tule antaa potilaalle ollenkaan, mikäli hänellä todetaan täydellinen DPD-entsyymin puutos. Osittaisessa DPD-entsyymin puutostilassa hoito aloitetaan pienennetyllä annoksella, mikä pohjautuu kansainvälisiin annossuosituksiin.

Peer reviewed

Country
Finland
Related Organizations
Keywords

Diarrhea, Biolääketieteet, Dihydropyrimidine Dehydrogenase Deficiency, Drug-Related Side Effects and Adverse Reactions, +diagnosis, +genetics, Antineoplastic Agents, ta3111, ta3122, +physiopathology, Cardiotoxicity, +adverse effects, Pyrimidines, Bone Marrow, Fluorouracil, Genetic Testing, Ulcer

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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Related to Research communities
UArctic