Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro.
Copyright policy )Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro.
To study the effect of 10-hydroxy-2-decenoic acid (HDA) on the macrophages activity of rats in vitro.To measure the effects of HDA on phagocytosis, the production of antitumor cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) in vitro.HDA 50, 100 mg.L-1 promoted phagocytic activity from 0.353 +/- 0.017 to 0.39 +/- 0.04 and 0.382 +/- 0.017 A, increased TNF and IL-1 production from 0.23 +/- 0.07% to 0.43 +/- 0.04%, 0.47 +/- 0.04% and from 2384 +/- 180 to 2943 +/- 295, 3825 +/- 450 dpm, respectively.The upregulating effects of HDA on phagocytosis of PMO and production of TNF, IL-1 contribute to the host antitumor and immunomodulating mechanism.
- Beijing Luhe Hospital Affiliated to Capital Medical University China (People's Republic of)
Male, Tumor Necrosis Factor-alpha, Antineoplastic Agents, Rats, Fatty Acids, Monounsaturated, Mice, Inbred C57BL, Rats, Sprague-Dawley, Mice, Adjuvants, Immunologic, Phagocytosis, Macrophages, Peritoneal, Animals, Female, Interleukin-1
Male, Tumor Necrosis Factor-alpha, Antineoplastic Agents, Rats, Fatty Acids, Monounsaturated, Mice, Inbred C57BL, Rats, Sprague-Dawley, Mice, Adjuvants, Immunologic, Phagocytosis, Macrophages, Peritoneal, Animals, Female, Interleukin-1
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