Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice.
Copyright policy )Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice.
To study effects of antihydatid drugs on glucosephosphate isomerase (GPI) and glyceraldehydephosphate dehydrogenase (GAPDH) in Echinococcus granulosus cyst wall.Mice infected with the parasite for 8-10 months were treated i.g. with mebendazole (Meb) or praziquantel (Pra). The activities of GPI and GAPDH in the cysts were measured by the formation of NADH or NADPH.GPI activity in the cyst wall was 197 +/- 103 U, while that of GAPDH was 25 +/- 13 U. When infected mice were treated i.g. with Meb 25-50 mg.kg-1.d-1 for 7-14 d, no apparent effect on the GAPDH activity in the cyst was found. In mice treated i.g. with praziquantel (Pra) 500 mg.kg-1.d-1 for 14 d, the GAPDH activity in the cyst wall was inhibited by 26.5%. As to GPI activity only the group treated i.g. with Meb 25 mg.kg-1.d-1 for 14 d showed 33.2% inhibition of the enzyme in the collapsed cyst wall.GPI and GAPDH are not the major targets attacked by the antihydatid drug.
Antiplatyhelmintic Agents, Mebendazole, Mice, Echinococcosis, Antinematodal Agents, Glucose-6-Phosphate Isomerase, Animals, Glyceraldehyde-3-Phosphate Dehydrogenases, Female, Praziquantel, Echinococcus
Antiplatyhelmintic Agents, Mebendazole, Mice, Echinococcosis, Antinematodal Agents, Glucose-6-Phosphate Isomerase, Animals, Glyceraldehyde-3-Phosphate Dehydrogenases, Female, Praziquantel, Echinococcus
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