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Wfs1 -puuduliku roti suhkurdiabeedi fenotüübi kirjeldamine

descriptionPublicationkeyboard_double_arrow_right Thesis 14 Aug 2017 Estonia, Germany Estonian Publisher:Tartu Ülikool
Authors: Koppel, Tuuliki;

handle: 10062/57518

Wfs1 -puuduliku roti suhkurdiabeedi fenotüübi kirjeldamine

Abstract

Wolframi sündroom (WS) on autosomaalne retsessiivne neurodegeneratiivne haigus, mida põhjustavad mutatsioonid WFS1 geenis. Sündroomi põhisümptomid on magediabeet, suhkurdiabeet, nägemisnärvi atroofia ja sensorineuraalne kurtus. Et uurida WS-i ja võimalikke WS-i vastaseid raviteraapiaid, on praegu disainitud eri laborites kolm Wfs1 -puudulikku hiiremudelit. Asjaolu, et nimetatud hiirtel pole seni selgelt näidatud suhkurdiabeedi kujunemist, ajendas Tartu Ülikooli teadlasi konstrueerima Wfs1 -mutantse roti. Käesolevas töös uuriti Wfs1 -mutantsel Wfs1 -ex5-KO232 rotil suhkurdiabeedi fenotüüpi ja selle tekkepõhjuseid. Leiti, et Wfs1 -puuduliku roti pankrease beeta-rakkudes on tõusnud ER-i stressitase, mistõttu beeta-rakud hävivad ja 11. elukuul tekib insuliinist sõltuv suhkurdiabeet. Seega võib Wfs1 -puudulik rott olla uus mudel suhkurdiabeedi ja võimalike WS-i vastaste ravimite uurimiseks.

Countries
Estonia, Germany
Related Organizations
Keywords

Wfs1 -puudulikkusega rott, diabetes mellitus, Wolframi sündroom, wolframiin 1, magistritööd, Wfs1

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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