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WFS1-puudulikkusega roti piklikaju neurodegeneratsiooni iseloomustus

descriptionPublicationkeyboard_double_arrow_right Thesis 14 Aug 2017 Germany, Estonia Estonian Publisher:Tartu Ülikool
Authors: Seppa, Kadri;

handle: 10062/57509

WFS1-puudulikkusega roti piklikaju neurodegeneratsiooni iseloomustus

Abstract

Wolframi sündroomi (WS) põhjustab WFS1 geeni bialleelne mutatsioon. WS-i iseloomustavad suhkurdiabeet, endokriinne väärtalitlus, optiline atroofia ning ajutüve progressiivne neurodegeneratsioon. Eelnevad uuringud on peamiselt keskendunud esimese sümptomina avalduva suhkurdiabeedi uurimisele ning sellest lähtuvalt on neurodegeneratsiooni uurimine jäänud tagaplaanile. Käesolevas töös uuriti WFS1-puudulikkusega roti piklikaju neurodegeneratsiooni. Uuringus nähti WFS1-puudulikel rottidel piklikaju ruumala vähenemist, ajast sõltuvat neuronaalset ER-i stressi ning WFS1 valgu ekspressiooni vähenemist oliivtuumade tasandis. Lisaks näidati esmakordselt WFS1 lokaliseerumist FOXP2 positiivsetes oliivtuuma neuronites. Töö tulemustest võib järeldada, et WFS1-puudulikel rottidel esineb WS-i patsientidega sarnane piklikaju neurodegeneratsiooni muster.

Countries
Germany, Estonia
Related Organizations
Keywords

ER-i stress, WFS1-puudulikkusega rott, neurodegeneratsioon, Wolframi sündroom, magistritööd, oliivtuumad

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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