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Likarska sprava
Article . 1999
Data sources: Europe PubMed Central
Claim

[The mutagenic and antimutagenic effects of immunomodulators].

descriptionPublicationkeyboard_double_arrow_right Article 25 Mar 1999 Russian Journal:Likars'ka sprava (issn: 1019-5297, Copyright policy )
Authors: L A, Sergeeva;

pmid: 10050470

[The mutagenic and antimutagenic effects of immunomodulators].

Abstract

In animal experiments (albino rats), stimulating and suppressive effects were studied of immunomodulating agents on the processes of chemical mutagenesis. Combination of different immunodepressants hardly ever intensifies cyclophosphamide-induced chromosomal rearrangement in rat bone marrow cells, with heparin exerting an antimutagenic effect, while corticosterone, when being administered at an augmented dose, appeared to enhance cyclophosphamide's mutagenic action. One-stage administration of immunostimulants and cyclophosphamide tended to weaken antimutagenic defence of cell genetic apparatus.

Keywords

Chromosome Aberrations, Adjuvants, Immunologic, Dose-Response Relationship, Drug, Leukocytes, Animals, Antimutagenic Agents, Bone Marrow Cells, Drug Interactions, Immunosuppressive Agents, Mutagens, Rats

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold