An attempt has been made to present a comprehensive review of the different factors relating to the phenomenon of ketosis. Particular emphasis has been placed on the mechanism of the origin of acetone bodies, as well as on the site of their formation and utilization. The more salient points relevant to the controversial subject of the relationship of the endocrine glands to ketosis have also been discussed. A study has been made of the effects on fat, carbohydrate and protein metabolism following the administration to mice {dba) of certain extracts of the anterior pituitary gland. It has been observed that fatty infiltration of the liver is invariably associated with ketosis. All the extracts studied resulted in an increase in the storage of glycogen and a decrease in the total fat content of the body whenever ketogenic activity was present, indicative of an enhanced oxidation of fat. The experimental results are of both a confirmatory and a supplementary nature.

Collip, J. (Supervisor)