Complex macromolecules, particularly proteins and nucleic acids, occupy a central position in the architecture and functioning of living matter. They are intimately connected with all phases of chemical and physical activity that constitute the life and reproduction of the cell. Yet these enormous molecules are synthesized within the cell from very small simple substances which may be obtained from the diet. As understanding of intermediary metabolism has increased, attention bas become focused upon certain small molecules or radicals, containing one, two or three carbon atoms, which appear repeatedly in various pathways.

Quastel, J. (Supervisor)