Present study was undertaken to investigate the antihelmintic potential of methanolic and aqueous extract of leaves of Prunus persica on adult Indian earthworm Pheritima posthuma. Prunus persica is an orchard tree native to China that bears a juicy edible peach. It belongs to the Rosaceae family. It is highly useful in treating inflammatory disorders. The leaves or powdered bark are excellent for inflammatory bowel disease and gastritis. Various concentrations (15, 30, 45, 60, 75 and 100 mg/ml) of methanolic and aqueous extracts were evaluated for antihelmintic activity by recording the time required for paralysis and death of worms. Albendazole (45 mg/ml) was used as reference standard and 1 % acacia in normal saline water as a control group. A significant anthelmintic affects were observed on live adult Pheretima posthuma worms in terms of the paralysis and death of the worms at different concentrations. The present study clearly demonstrated the antihelmenthic activity of Prunus persica supporting the traditional claim.