Cardiovascular-kidney-metabolic (CKM) syndrome is a significant contributor to the progressive decline in renal function, often leading to advanced chronic kidney disease. We report a 55-year-old man with a history of obesity, diabetes, and hypertension who was diagnosed with renal cell carcinoma (RCC) and underwent unilateral nephrectomy for his treatment, which led to decreased kidney function. The patient showed signs of improvement in glomerular filtration rate (GFR) and proteinuria after weight loss with combination therapy for CKM, including renin-angiotensin-aldosterone system (RAAS) inhibitors, sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitors), and glucagon-like peptide-1 receptor agonists (GLP-1RA).