The duodenum is thought to be the most prevalent site of primary small bowel adenocarcinoma, and the disease mostly affects the descending part of the duodenum. Although the majority of small intestine adenocarcinomas are caused by duodenal adenocarcinomas, it is extremely uncommon for them to occur in the duodenal bulb. We report the case of an 80-year-old female with a complex medical history who presented with symptomatic anemia secondary to gastrointestinal (GI) blood loss secondary to adenocarcinoma of the duodenal bulb.