Ciprofloxacin is a widely used empiric antibiotic that may cause adverse reactions, including leukocytoclastic vasculitis (LCV). We present the case of a 51-year-old woman diagnosed with pyelonephritis, who developed cutaneous vasculitic lesions one day after ciprofloxacin administration. The differential diagnosis was broad and included autoimmune diseases, which were ruled out through extensive testing. A skin biopsy confirmed LCV. This rare drug-induced reaction was successfully managed by discontinuing ciprofloxacin, and the patient made a full recovery within five days without the need for corticosteroid treatment.