Third molar extraction is one of the most common interventions in oral surgery. It is usually associated with postoperative pain, edema, and trismus. The severity of these sequelae can be related to the amount of surgical trauma and the duration of the extraction. Prevention strategies, including different local and systemic medications, autologous platelet concentrates, and physical therapy, can be beneficial for reducing postoperative discomfort and risk of complications. This case report compares the local application of platelet-rich plasma (PRP) and the systemic use of the homeopathic combination medication Lymphomyosot to reduce the postoperative sequelae after third molar extraction. The study results revealed the superior qualities of PRP in reducing postoperative edema and trismus, while both methods gave similar results regarding pain control.