A 69-year-old highly comorbid female patient presented to the emergency department with sepsis following a month of fevers, myalgias, and lethargy. Abdominal imaging revealed an adrenal abscess, an aspirate of which grew Campylobacter fetus (C. fetus). The patient was treated with meropenem and then azithromycin; however secondary infection of the abscess cavity with an extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) and failure of source control led to an extended clinical course. This case highlights the only documented case of C. fetus adrenal abscess, and a literature review of C. fetus-associated abscess presentations is provided.