Collodion baby is a rare congenital condition marked by a parchment-like membrane covering the body, often leading to complications such as bilateral ectropion. This condition poses risks of exposure keratopathy and other ocular issues. We present a case series of five infants with congenital bilateral ectropion associated with collodion babies, all born prematurely. Each case was treated with varying management approaches, including topical therapies and surgical interventions, with Case 1 experiencing recurrence despite surgical intervention, while the rest four cases demonstrated successful outcomes through appropriate treatments. Regular follow-up was essential for monitoring. Early and individualized treatment strategies are crucial for preventing complications in collodion babies with ectropion. This case series highlights the need for tailored management to optimize patient outcomes in this rare condition.