Introduction Plantar fasciitis, a common cause of heel pain, is often treated conservatively. Platelet-rich plasma (PRP) injections have emerged as a promising treatment option. This study aimed to evaluate the efficacy of autologous PRP injections for plantar fasciitis. The objective of this study was to assess the effectiveness of autologous PRP injections delivered at the plantar fascia origin in reducing pain (measured by the Visual Analog Scale (VAS) pain intensity score) in patients with plantar fasciitis. Materials and methods A prospective cohort study was conducted at the Department of Orthopedics, Hayatabad Medical Complex, Peshawar. Patients with plantar fasciitis, a VAS pain score ≥ 7, and failure of conservative treatment were included. A single injection of autologous PRP was administered to the plantar fascia. Pain reduction was assessed using the VAS score at a 12-week follow-up. Result The study included 163 patients. Success was achieved in 80.3% of cases, showing that autologous PRP injection resulted in significant pain improvement in patients with plantar fasciitis (p≤0.05). An increased likelihood of successful treatment was observed in individuals with symptoms lasting less than 12 months. No other variables (gender, age group, residence, literacy) significantly impacted treatment efficacy. Conclusion Autologous PRP injections may be a promising treatment option for plantar fasciitis, particularly when administered early. Further research is needed to validate these findings and explore optimal patient selection criteria.