Sutures play a crucial role in closing mucosal incisions during endoscopic nasal surgery. The duration until the spontaneous drop of polyglactin 910 (Vicryl) sutures in the nasal cavity remains uncertain. To investigate this, we examined the medical records of patients who underwent septoplasty, inferior turbinate reduction, or endoscopic modified medial maxillectomy with polyglactin 910 sutures. The sutures were counted and monitored during follow-up visits, and removal occurred only if patients reported discomfort. In our study of 124 patients, a total of 453 sutures were placed during surgery. Eighteen sutures had to be intentionally removed due to discomfort. Importantly, no surgical site infections were observed during the follow-up period. We found that sutures on the lateral nasal wall persisted longer than those on the nasal septum, with respective half-lives of 70 days and 64 days (p = 0.0071). In conclusion, using polyglactin 910 sutures in nasal surgery and allowing them to dissolve naturally in the submucosa is an effective approach. The sutures exhibit longer persistence on the lateral nasal wall compared to the nasal septum.