Silver nanoparticles (AgNPs) have been effectively applicable in most regions because of their antimicrobial activity against various microorganisms. AgNPs can be applied in disinfection and prophylaxis and to prevent diseases of the oral cavity. Because of developing interest in AgNPs, this article shows the application of AgNPs in various fields of dentistry such as nanocomposites, implant coatings, inhibiting the growth of bacteria, preventing dental caries, biofilm, infectious microbes, local anesthesia, microorganisms causing damage to the pulp, as well as deals with diseases such as oral malignancies due to their antitumor properties. AgNPs have a potential system with major features including antibacterial, anti-inflammatory, and anticancer action. They may also be used as a sustained drug delivery vehicle.