SUMOylation in  Trypanosoma brucei

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 08 Oct 2013 English Publisher:PeerJJournal:PeerJ, volume 1, page e180 (eissn: 2167-8359,

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Authors: Klein, Cornelia Andrea; Droll, Dorothea; Clayton, Christine;

doi: 10.7717/peerj.180

pmid: 24133638

pmc: PMC3796365

SUMOylation in Trypanosoma brucei

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Abstract

Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 (Tb927.2.2460) and the SUMO-specific protease SENP (Tb927.9.2220) are involved in SUMOylation and SUMO removal, respectively.

Related Organizations

Heidelberg University
Germany

Keywords

Small ubiquitin-like modifier, Heat shock, SUMO, Oxidative stress, QH301-705.5, R, Medicine, Trypanosoma brucei, Cell Biology, Biology (General)

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