The contrasting phylodynamics of human influenza B viruses
Copyright policy )The contrasting phylodynamics of human influenza B viruses
A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
- University of Melbourne Australia
- Duke University United States
- National University of Singapore Singapore
- University of Adelaide Australia
- Canterbury District Health Board New Zealand
Models, Molecular, Influenza Virus, Time Factors, Glycosylation, 3207 Medical Microbiology, 32 Biomedical and Clinical Sciences, Hemagglutinin Glycoproteins, Influenza Virus, influenza virus, Madin Darby Canine Kidney Cells, Models, 2.2 Factors relating to the physical environment, Viral, Biology (General), 3202 Clinical Sciences, Antigens, Viral, Phylogeny, Genome, General Neuroscience, Q, R, 3 Good Health and Well Being, General Medicine, Infectious Diseases, Genomics and Evolutionary Biology, Influenza A virus, Pneumonia & Influenza, Medicine, epidemiology, Asparagine, Infection, Reassortant Viruses, Human, Hemagglutinin Glycoproteins, 570, Victoria, Evolution, QH301-705.5, infectious disease, Science, Genome, Viral, General Biochemistry, Genetics and Molecular Biology, Evolution, Molecular, Age Distribution, Dogs, Genetic, Biodefense, evolution, Influenza, Human, genomics, Animals, Humans, viruses, Influenza B viruses, human, Antigens, Selection, Genetic, Selection, antigenic drift, General Immunology and Microbiology, evolutionary biology, microbiology, Molecular, Genetic Variation, Influenza, 3107 Microbiology, Influenza B virus, Emerging Infectious Diseases, DRNTU::Science::Biological sciences::Human anatomy and physiology, 31 Biological Sciences, New Zealand
Models, Molecular, Influenza Virus, Time Factors, Glycosylation, 3207 Medical Microbiology, 32 Biomedical and Clinical Sciences, Hemagglutinin Glycoproteins, Influenza Virus, influenza virus, Madin Darby Canine Kidney Cells, Models, 2.2 Factors relating to the physical environment, Viral, Biology (General), 3202 Clinical Sciences, Antigens, Viral, Phylogeny, Genome, General Neuroscience, Q, R, 3 Good Health and Well Being, General Medicine, Infectious Diseases, Genomics and Evolutionary Biology, Influenza A virus, Pneumonia & Influenza, Medicine, epidemiology, Asparagine, Infection, Reassortant Viruses, Human, Hemagglutinin Glycoproteins, 570, Victoria, Evolution, QH301-705.5, infectious disease, Science, Genome, Viral, General Biochemistry, Genetics and Molecular Biology, Evolution, Molecular, Age Distribution, Dogs, Genetic, Biodefense, evolution, Influenza, Human, genomics, Animals, Humans, viruses, Influenza B viruses, human, Antigens, Selection, Genetic, Selection, antigenic drift, General Immunology and Microbiology, evolutionary biology, microbiology, Molecular, Genetic Variation, Influenza, 3107 Microbiology, Influenza B virus, Emerging Infectious Diseases, DRNTU::Science::Biological sciences::Human anatomy and physiology, 31 Biological Sciences, New Zealand
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