Linezolid is an antibiotic effective against resistant gram-positive bacteria. While side effects are typically mild, myelosuppression can occur, with pancytopenia being a rare but serious condition. We report on a 94-year-old woman who developed pancytopenia following linezolid treatment of cellulitis and myositis. Despite initial stability, her condition necessitated rehospitalization. Hematologic recovery ensued after linezolid was discontinued. This case highlights the need for awareness of linezolid-induced myelosuppression, especially with risk factors like advanced age and sodium–glucose cotransporter-2 inhibitor use. Clinicians should monitor for hematologic adverse effects of linezolid, especially in patients with associated risk profiles.