The primary focus of this thesis is the evaluation through experimental and numerical investigations of pipeline performance under earthquake-induced ground deformation. This kind of deformation is associated with soil liquefaction, landslides, fault rupture, tectonic uplift and subsidence and settlement of loose granular soils. A large part of this thesis involves the earthquake response of pipelines with defects, e.g., cracks and/or leaking joints, rehabilitated with cured-in-place linings (CIPLs). The thesis begins with the description of a series of full-scale static and dynamic axial tension tests to characterize the tensile capacity of CIPL-reinforced pipelines. The CIPL de-bonding is of great importance for the accommodation of tensile deformation. The amount of CIPL de-bonding is a function of the CIPL properties (i.e. stiffness, tensile strength) with respect to the pipe/CIPL interface bond strength, which increases with increasing internal pressure. A one-dimensional finite element model is developed that accounts for the CIPL de-bonding mechanism as a Mode II fracture propagation phenomenon, including the enhanced pipe/CIPL interface strength in the presence of internal pressure. Seismic wave interaction with CIPL-reinforced pipelines subjects them to alternating tension and compression as the waves propagate through the ground. The combinations of ground velocity amplitude and pulse period that cause lining deformation are evaluated through analytical models of seismic wave/pipeline interaction and finite element simulations. CIPL-strengthened pipeline response to permanent ground deformation was also investigated through large-scale fault rupture experiments and numerical simulations. Fault rupture test results on pipelines with CIPLs are presented and compared with test results on unlined pipelines, to assess the effectiveness of the CIPLs for seismic retrofit. The results of the numerical model developed in this work that accounts for de-bonding between the lining and pipe as Mode II fracture ...