Background: Dermatophytosis has lately become widespread in India. The presence of dermatophytosis for six months or more is described as chronic dermatophytosis. Chronic dermatophytosis may significantly affect one’s quality of life. The aim of this study was to determine the impact of chronic dermatophytosis on quality of life. Materials and Methods: A total of 220 cases of chronic dermatophytosis were included in the study for the Dermatology Life Quality Index questionnaire. Statistical analysis was done using univariate/multivariate and regression analysis to analyze the effect of chronic dermatophytosis on quality of life. p < 0.05 was considered statistically significant. Results: Among the total 220 cases, 47.27% were males (mean age: 30.53 yrs.), and 52.72% were females (mean age: 36.24 yrs.). The mean DLQI score was 11.054. DLQI was significantly (p < 0.05) influenced by duration of illness and body surface area of the patient. Conclusion: Dermatophytosis is known to affect the quality of life of all patients, whereas chronic dermatophytosis causes a remarkably negative outcome on quality of life. Hence, reassurance and counseling of patients suffering from chronic disease is required along with timely and precise treatment. Key words: Chronic dermatophytosis, Dermatology Life Quality Index, Dermatophytosis