The aim of this work is to demonstrate the relationships established between an economy’s productive sectors and the water consumption generated during their productive processes. We study de Andalusian reality, region of the South Spain characterized by its scarcity, and we will examine if the excessive dependence on water resources which may occur in some productive sectors might affect not only the conservation and quality of this resource, but also have negative effects upon the stability of the economy itself. A mixed methodology has been used, combining Input-Output analysis with Graphs Theory. We obtain a water Input-Output model and an interrelationship matrix which is analysed by Graphs Theory. The main conclusion is that Andalusian’s economic specialisation does not make a positive contribution water conservation and, moreover, the regional economy’s sustainability might be seriously endangered if the authorities do not take into account water limitations in their economy policy.